With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.51206-40-7,1,4-Dibromoisoquinoline,as a common compound, the synthetic route is as follows.,51206-40-7
A solution of 1 ,4- dibromoisoquinoline (230 mg, 0.8 mmol), 4-methoxybenzene sulfonamide (300 mg, 1.6 mmol), Cul (60 mg, 0.3 mmol), K2C03 (1.18 g, 8.5 mmol), and N1 ,N2 -dimethylethane-1 ,2-diamine (142 mg, 1.6 mmol) in MeCN (6 ml.) was heated at 70 C for 7 days. On completion, the reaction mixture was quenched with H20 (20 ml_), and the yellow-colored solid was collected by filtration. The collected solid was washed with Et20 (10 ml.) and dried to yield the title compound.
The synthetic route of 51206-40-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS; MOORE, Terry; LAZZARA, Phillip; DAVID, Brian; RICHARDSON, Benjamin; JAIN, Atul, D.; (87 pag.)WO2019/195348; (2019); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem