With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.891785-28-7,6-Bromoisoquinolin-3-amine,as a common compound, the synthetic route is as follows.
891785-28-7, To an oven dried schlenck flask was added [(2R)-tetrahydrofuran-2-ylj-[4-[4-(4,4,5,5- tetramethyl- 1,3 ,2-dioxaborolan-2-yl)phenoxyj -1 -piperidylj methanone (0.11 g, 0.26 mmol), 6- bromoisoquinolin-3-ylamine (0.09 g, 0.39 mmol), tetrakis(triphenylphosphine)palladium(0) (0.03 g, 0.03 mmol), iN Na2CO3 (0.79 mL, 0.79 mmol), followed by i,4-dioxane (2 mL) and was degassed under an atmosphere of argon for 5 mm and was heated at 99 C for 2 h. The reaction was cooled, filtered through a pad of celite, washed with iN Na2CO3/water/brine, dried over sodium sulfate, and concentrated. The product was purified using the Gilson (0. i%TFA in water/0. 1% TFA in acetonitrile gradient), diluted clean fractions with DCM, washed with iN Na2CO3/brine, dried over sodium sulfate, and concentrated. {4-[4-(3-aminoisoquinolin-6-yl)- phenoxyj-piperidin-i-yl}-(R)-tetrahydrofuran-2-yl-methanone was isolated as a solid (0.04 g, 34%). Analysis: LCMS m/z = 403 (M+i). ?H NMR (DMSO-d6) oe: 8.78 (s, iH), 7.84 (d, iH, J =8.6 Hz), 7.70 (m, 3H), 7.44 (m, 2H), 7.11 (m, 2H), 6.65 (s, iH), 5.91 (s, 2H), 4.68 (m, 2H), 3.76 (m, 4H), 3.41 (m, iH), 3.29 (m, iH), 2.01 (br m, 4H), i.84 (m, 2H) i.5i-i.65 (br m, 2H).
891785-28-7 6-Bromoisoquinolin-3-amine 45789831, aisoquinoline compound, is more and more widely used in various fields.
Reference£º
Patent; CEPHALON, INC.; BECKNELL, Nadine, C.; DANDU, Reddeppa, Reddy; DORSEY, Bruce, D.; GOTCHEV, Dimitar, B.; HUDKINS, Robert, L.; WEINBERG, Linda; ZIFICSAK, Craig, A.; ZULLI, Allison, L.; (411 pag.)WO2016/205633; (2016); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem