893566-75-1, Tert-butyl 8-bromo-3,4-dihydroisoquinoline-2(1H)-carboxylate is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,893566-75-1
Compound 14.2 (200 mg, 0.64 mmol) was dissolved in dry tetrahydrofuran (10 ml) andcooled to -78 O (dry ice, acetone). nButyllithium (2.4M in hexanes, 0.40 ml, 0.96 mmol) wasadded dropwise then the mixture was stirred at -78 00 for 1 h. Dry N,N-dimethylformamide (0.1 ml, 1.29 mmol) was added then stirring continued at 780C for 30 mm before allowing to RT for 1 h. The reaction mixture was quenched with water then extracted three times with ethyl acetate. The organic extract was dried over sodium sulfate, filtered and evaporated.The residue was purified via flash silica chromatography (DCM I EtOAc 5percent) to provide compound 14.3 (80 mg, 45percent) as a colourless oil. 1H NMR (CDCI3, 400 MHz) O 1.35 (5, 9H), 2.90 (m, 2H), 3.65 (m, 2H), 5.02 (5, 2H), 7.36 (m, 2H), 7.67 (t, 1H), 10.13 (5, 1H). UPLC-MS (short basic) rt 0.85 (262 [M+H]), 95percent pure.
As the paragraph descriping shows that 893566-75-1 is playing an increasingly important role.
Reference£º
Patent; THE UNIVERSITY OF SHEFFIELD; RICHARDS, Gareth; SKERRY, Timothy, M.; HARRITY, Joseph, P.A.; ZIRIMWABAGABO, Jean-Olivier; TOZER, Matthew, J.; GIBSON, Karl, Richard; PORTER, Roderick, Alan; BLANEY, Paul, Matthew; GLOSSOP, Paul, Alan; (369 pag.)WO2018/211275; (2018); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem