With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.215453-51-3,7-Bromo-1-chloroisoquinoline,as a common compound, the synthetic route is as follows.
215453-51-3, 7-Bromo-1-chloroisoquinoline (1-1) (79 mg, 0.327 mmol, 1.0 equiv) and Ethyl carbazate (34 mg, 0.33 mmol, 1.0 equiv) were suspended in EtOH (1.5 mL). The reaction mixture was irradiated in microwave at 170 C. for 40 minutes. The crude mixture was purified with reverse phase HPLC (H2O/CH3CN gradient w/0.1% TFA present) to yield 9-bromo[1,2,4]triazolo[3,4-a]isoquinolin-3(2H)-one (1-2). LRMS m/z (M+H) 263.9 and 264.9 found, 264.1 and 265.1 required.
The synthetic route of 215453-51-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Arrington, Kenneth L.; Brnardic, Edward J.; Dudkin, Vadim Y.; Fraley, Mark E.; Huang, Shaei Y.; Wang, Cheng; US2007/254879; (2007); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem