6624-49-3, Isoquinoline-3-carboxylic acid is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: The compounds 1-9 were synthesized using themixed anhydrides method of peptide synthesis (18).The suitable acid (10 mM) was dissolved in DMF(15 mL) and THF (15 mL) was added. Next N-methylmorpholine (10 mM, 1.1 mL) was added andthe mixture was stirred under nitrogen and chilled to-15 O C. Isobutyl chloroformate (10 mM, 1.3 mL) wasadded dropwise to keep the temperature below -15 O C. Then, the suitable amine: 2- or 4-fluorobenzy-lamine (2-F-BZA, 4-F-BZA); 2- or 4-methoxyben-zylamine (2-OMe-BZA, 4-OMe-BZA); 3- or 4-methylbenzylamine (3-Me-BZA, 4-Me-BZA) or 1-naphthylmethylamine (10 mM) in THF was added insmall portions and the reaction mixture was stirred at -15 O C for 30 min and at room temperature for 1 h.The solution was concentrated in vacuo and theresidue was dissolved in CHCl 3 (40 mL). This solu-tion was washed with 20 mL portions of 1M HCl,saturated NaHCO 3 solution and saturated NaCl solu-tion, then dried with anhydrous MgSO 4 , filtered andconcentrated in vacuo. The obtained compoundswere purified by crystallization with EtOAc/hexaneor MeOH/Et 2 O. All stages of the synthesis were con-trolled by TLC. The purity and identity of the finalcompounds were determined by HPLC, elementalanalyses, 1 H NMR, MS. The elemental analyses werewithin ¡À 0.4percent of the theoretical value. The analyticaldata confirmed that the purity of the products was ?95percent. The general procedure for the synthesis of theobtained compounds is shown in Schemes 1 and 2., 6624-49-3
As the paragraph descriping shows that 6624-49-3 is playing an increasingly important role.
Reference£º
Article; Strupi?ska, Marzanna; Rostafi?ska-Suchar, Grazyna; Jakubowicz, Bart?omiej; Klimkiewicz, Paulina; Lal, Ewelina; Oczkowski, Mateusz; Prochniak, Ewa; Pirianowicz-Chaber, Elzbieta; Mazurek, Aleksander P.; Acta poloniae pharmaceutica; vol. 74; 4; (2017); p. 1111 – 1118;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem