With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.105627-79-0,Isoquinoline-5-sulfonyl chloride hydrochloride,as a common compound, the synthetic route is as follows.
Intermediate compound 3a (315 mg, 0.600 mmol) was dissolved in anhydrous DCM. 5-isoquinoline sulfonyl chloride ¡¤ HCl (190.3 mg, 0.721 mmol) and TEA (100 ml, 0.721 mmol) were added to the mixture, and the mixture was stirred at room temperature for 2 hours.After confirming the completion of the reaction,After acidification with saturated ammonium chloride solution and extraction with DCM,Dried over anhydrous MgSO4,Filtered and rotary evaporated.Purification of the compound was purified by column chromatography (methanol: chloroform = 1: 45) to obtain white crystals; Yield: 54.0%, 105627-79-0
105627-79-0 Isoquinoline-5-sulfonyl chloride hydrochloride 13116932, aisoquinoline compound, is more and more widely used in various fields.
Reference£º
Patent; Gwangju Institute of Science and Technology; Kim, Yong Chul; Lee, Ka Eun; (33 pag.)KR101732732; (2017); B1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem