34784-05-9, 6-Bromoisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A solution of 6-bromoisoquinoline (2.08 g, 10 mmol) in dry tetrahydrofuran (20 mL) at -78 C was added dropwise to n-butyl lithium (1 .6 M in hexane, 6.25 mL, 10 mmol) and stirred at -78 C for 15 minutes. The product of Example 3b (770 mg, 5 mmol) in tetrahydrofuran (5 mL) was added and stirred at -78 C for 30 minutes and then slowly warmed to room temperature and stirred for an additional 2 hours. The mixture was quenched with saturated aqueous ammonium chloride and the organics were extracted with ethyl acetate. The combined organic phase was washed with brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure. Purification of residue by silica gel column chromatography afforded a yellow solid. The solid was recrystallized from petroleum ether and ethyl acetate to give the title compound as a white solid (778 mg, Yield: 55%). Rf = 0.4 (2: 1 petroleum ether/ethyl acetate); 1 H NMR (400 MHz, CDCI3) delta 9.20 (s, 1 H), 8.49 (d, J = 5.6 Hz, 1 H), 7.93-7.90 (m 2 H), 7.64-7.60 (m, 2 H), 5.28 (d, J = 5.6 Hz, 1 H), 2.02 (d, J – 5.6 Hz, 1 H), 1 .91 -1 .88 (m, 1 H), 1 .56-1 .47 (m, 4 H), 1 .37-1 .26 (m, 2 H), 1 .23 (s, 3 H), 1 .12 (s, 3 H), 1 .01 -0.93 (m, 1 H), 0.56 (d, J = 6.4 Hz, 3 H) ppm; Mass spectrum (ESI +ve) m/z 284 (M + H+).
34784-05-9, The synthetic route of 34784-05-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BIKAM PHARMACEUTICALS, INC.; GARVEY, David, S.; GREENWOOD, Jeremy, R.; FRYE, Leah, L.; WO2013/82000; (2013); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem