With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.486-73-7,Isoquinoline-1-carboxylic acid,as a common compound, the synthetic route is as follows.
General procedure: 2-Pyridinecarboxylic, 2-quinolinecarboxylic or 1-isoquinolinecarboxylic acid (1.5 mmol) and NEt3 (1.5 mmol,152 mg, 209 mL) were added to dry NMP (2.1 mL) in a Schlenk flaskunder Ar atmosphere. At 0 C, diphenyl phosphoryl azide(1.6 mmol, 440 mg, 345 mL) was added drop-wise and the reactionmixture was stirred at 35 C for 1 h. N-Oxide (1 mmol) was thenadded in one portion and the reaction mixture was stirred at 70 Cfor 20 h. The mixture was then poured into water (50 mL) andextracted with AcOEt (3 x 20 mL). Combined organic extracts werewashed with brine (5 x 30 mL) dried over anhyd. Na2SO4 andevaporated. Products 2 were purified by column chromatographyon silica gel using hexaneseAcOEt 2:1 or tolueneeAcOEt 2:1, thenAcOEt as eluent.
486-73-7, The synthetic route of 486-73-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Bukowska, Patrycja; Piechowska, Joanna; Loska, Rafa?; Dyes and Pigments; vol. 137; (2017); p. 312 – 321;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem