Bhagat, Kavita published the artcileMicrowave-assisted synthesis of 11-substituted-3,3-dimethyl-2,3,4,5,10,11-hexahydrodibenzo[b,e][1,4]diazepin-1-one derivatives catalysed by silica supported fluoroboric acid as potent antioxidant and anxiolytic agents, Recommanded Product: 2,3-Dimethoxybenzaldehyde, the main research area is dimethyl hexahydrodibenzodiazepinone preparation antioxidant anxiolytic activity green chem; phenylenediamine dimedone aldehyde fluoroboric acid catalyst cyclocondensation microwave irradiation.
A novel series of benzodiazepine derivatives I [R = Ph, 4-chlorophenyl, 4-bromophenyl, etc.] as antioxidant and anxiolytic agents were synthesized. All the compounds were obtained in good yield by facile synthesis. To check their antioxidant potential, DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical scavenging assay was performed. Among all the synthetics seven derivatives I [R = 3-methoxyphenyl, 4-nitrophenyl, 3-methyl-2-thienyl, cinnamyl, 1-naphthyl 3,4-dichlorophenyl, 3-bromophenyl] exhibited IC50 values ranging from 76 to 489 nM. These seven compounds were further evaluated to check their binding abilities towards the benzodiazepine binding site on GABAA receptors. Three best-fit ligands I [R = 3-methoxyphenyl, 1-naphthyl, 3,4-dichlorophenyl] were further evaluated for their anxiolytic effect by using three in-vivo mice models i.e. Elevated Plus Maze, Light & Dark box, and Mirror Chamber model. The study revealed that compounds I [R = 3,4-dichlorophenyl, 1-naphthyl] showed the best anxiolytic effect as compared to standard drug diazepam even at an oral dose of 1.0 mg/kg.
Medicinal Chemistry Research published new progress about Antioxidants. 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Recommanded Product: 2,3-Dimethoxybenzaldehyde.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem