147497-32-3, 6-Bromo-3,4-dihydroisoquinolin-1(2H)-one is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General Procedure: To a stirred solution of the bromoisoquinoline 3 (0.25 g, 1.1 mmol) in toluene (10 mL), under argon atmosphere, 2M (aq) K2CO3 (0.55 mL, 1.1 mmol,) and Pd(PPh3)4 (80 mg, 6 mol%) were added. The solution was stirred for 20 min at r.t. Then, a solution of 4-pyridylboronic acid (0.22 g, 1.65 mmol) in EtOH (15 mL) was added, and the reaction moisture was heated up to 90 C for 6 h. After that, the mixture was cooled to room temperature before the addition of H2O2 (30%, 1 mL) and stirred for a further 1h. The desired product was then extracted with CH2Cl2 (3 ¡Á 25 mL), the combined organic layers were washed with water, and brine, dried over anhydrous Na2SO4, filtered, and concentrated under reduced pressure. The crude product was purified by flash column chromatography on silica gel (2:1 AcOEt:hexane) to give the desired product., 147497-32-3
147497-32-3 6-Bromo-3,4-dihydroisoquinolin-1(2H)-one 21865450, aisoquinoline compound, is more and more widely used in various fields.
Reference£º
Conference Paper; Ortega, Raquel; Huebner, Harald; Gmeiner, Peter; Masaguer, Christian F.; Bioorganic and Medicinal Chemistry Letters; vol. 21; 9; (2011); p. 2670 – 2674;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem