105627-79-0, Isoquinoline-5-sulfonyl chloride hydrochloride is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Isoquinoline-5-sulfonyl chloride hydrochloride (33 g, prepared according to the method described in Japanese Patent Unexamined Publication (Kokai) No. 57-200366) was added to dichloromethane (300 ml) and water (300 ml), added with sodium hydrogencarbonate with vigorous stirring until pH of the aqueous layer became 5 to 6. The reaction mixture was further extracted three times with dichloromethane, and the organic layer was dried over anhydrous magnesium sulfate. This solution was added dropwise to a solution of ethylenediamine (30 g) in dichloromethane (600 ml) over 2 hours with ice cooling and stirred at room temperature for 30 minutes. After completion of the reaction, the reaction mixture was added with diluted hydrochloric acid with vigorous stirring to adjust pH of the aqueous layer to about 8. The organic layer and the aqueous layer were separated, and then the aqueous layer was collected and added with potassium carbonate to obtain a saturated solution, which was extracted with dichloromethane (600 ml). The organic layer was dried over anhydrous magnesium sulfate, and then the solvent was evaporated under reduced pressure to obtain the title compound (22.9 g).
105627-79-0, As the paragraph descriping shows that 105627-79-0 is playing an increasingly important role.
Reference£º
Patent; Yamada, Rintaro; Seto, Minoru; US2005/20623; (2005); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem