With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.486-73-7,Isoquinoline-1-carboxylic acid,as a common compound, the synthetic route is as follows.
Isoquinoline carboxylic acid a (5.0 g, 28.9 mmol), N.O-dimethy-hydroxylamine hydrochloride (3.1 g, 31.8 mmol) EDC (6.1 g, 32 mmol), DIPEA (5.7 mL, 32 mmol) and MeCN (50 mL) were mixed together and stirred at rt overnight. The MeCN was removed under reduced pressure and the residue partitioned between water (200 mL) and EtOAc (200 mL). The phases were separated and the aqueous phase was extracted with EtOAc (2 x 50 mL). The combined organic phases were b as a colorless solid.
486-73-7, The synthetic route of 486-73-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GENENTECH, INC.; WO2006/69063; (2006); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem