Yang, Lifang published the artcileDesign, synthesis and biological evaluation of a series of new resveratrol analogues as potential anti-cancer agents, SDS of cas: 104-01-8, the main research area is benzeneacetic acid benzaldehyde Perkin condensation reaction; diphenylpropenoic acid preparation antitumor SAR apoptosis mol docking; anti-cancer; molecular docking; resveratrol; synthesis of resveratrol analogues; tubulin.
A series of novel resveratrol derivatives I [R1 = 3,4-Cl2, 2-OCF3O, 2-NO2-5-Cl, etc; R2 = 3,4,5-(MeO)3, 4-MeO, 3,5-Me2] were designed, synthesized and evaluated as anti-cancer agents. Most of compounds I showed significant anti-proliferative activities against three human cancer cell lines (HepG2, A549 and Hela). Among these compounds, compound I [R1 = 2-Cl-5-CF3, R2 = 4-MeO (II)] displayed the most potent inhibitory activity and showed low cytotoxic activity. Cell apoptosis and cell cycle assays demonstrated that compound II significantly induced apoptosis (p < 0.001) and arrested cell cycle at S phase. Immunofluorescence microscopy anal. showed compound II disrupted the tubulin network. Docking simulations supported the pharmacol. results of compound II. It was believed that this work was very useful for designing a new series of tubulin inhibitors. Royal Society Open Science published new progress about Antitumor agents. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, SDS of cas: 104-01-8.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem