Bhukya, Balakishan published the artcileBrevifoliol ester induces apoptosis in prostate cancer cells by activation of caspase pathway, SDS of cas: 104-01-8, the main research area is brevifoliol ester preparation apoptosis prostate cancer caspase; Ehrlich ascites carcinoma; acute oral toxicity; anticancer; apoptosis; brevifoliol analogues.
Prostate cancer is fourth most abundant cancer type around the globe. Brevifoliol, a rearranged taxoid from Taxus walllichiana needles has been derivatized as C5 esters using Steglich esterification reaction. Seventeen diverse analogs were evaluated against a panel of human cancer cell lines by MTT assay. Among these, two of the semi-synthetic analogs, i.e., 13 and 16 exhibited potent cytotoxicity, selectively against PC-3, prostate cancer cell lines. In cell cycle anal., analog 13 induced S and G2/M phase arrest and induced apoptosis by activating caspase-3. Compound 13 showed moderate efficacy in in-vivo Ehrlich ascites carcinoma in Swiss albino mice. Further, compound 13 was found to be safe in Swiss albino mice up to 1,000 mg/kg dose in acute oral toxicity. Brevifoliol ester 13 may further be optimized for better efficacy.
Chemical Biology & Drug Design published new progress about Antitumor agents. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, SDS of cas: 104-01-8.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem