Gorle, Sridevi published the artcileSynthesis and anticancer activity of novel pyrazolo[4′,3′:5,6]pyrano[2,3-d] pyrimidin-5(2H)-one derivatives, Formula: C9H10O3, the main research area is pyrazolopyranopyrimidinone preparation antitumor SAR.
A novel sequence of pyrazole connected pyrano[2,3-d]-pyrimidin-5(2H)-ones, compounds I [R = 4-Me, 2-Cl, 2-Br, etc.] were designed, prepared and screened for their cytotoxicity against four human cancer cell lines like MCF-7 (breast), HeLa (cervical), CaCo2 (colorectal) and HepG2 (liver) by MTT assay. Most of the tested mols. were exhibited good to excellent cytotoxicity against all tested cell lines when compared to the standard drug Doxorubicin. Amongst all the synthesized target compounds, the mols. compounds I [R = 2,3,4-triMeO, 3,4,5-triMeO] exhibited the excellent anticancer activity against all the human MCF-7, HeLa, CaCo2 and HepG2 tumor cell lines, with the inhibitory concentration (IC50) values of 14, 14, 13, & 16μg mL-1 and 16, 14, 15 & 17μg mL-1, resp., while, compounds I [R = 2,3-diMeO, 3,4-diMeO] revealed good inhibitory activity against all screened cell lines with the IC50 values of 22, 25, 25 & 24μg mL-1 and 21, 20, 21, & 20μg mL-1. All the novel target mols. were determined and characterized by various spectroscopic (1H NMR, 13C NMR and HR-MS) anal.
Chemical Data Collections published new progress about Antitumor agents. 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Formula: C9H10O3.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem