Maadwar, Sasikala published the artcileA facile and an efficient synthesis of 3, 3-disubstituted oxindole scaffolds and their cytotoxic properties, Category: isoquinoline, the main research area is diphenyl indolinone preparation antitumor activity SAR.
3,3-Disubstituted oxindole derivatives I [R = H, Me, Cl, etc.; R1 = 1,2-dimethoxy, 1,3-dimethoxy, 1,4-dimethoxy, 1,3,5-trimethoxy] were synthesized by treating isatins with electron rich benzene derivatives at room temperature by using BF3·O(Et)2 as catalyst which reduced the synthesis time. The compounds I were evaluated for cytotoxic activity against human breast cancer cells (MCF7) and human ovarian carcinoma cells (SKVO3) by using MTT assay. Compounds I [R = Cl, Br; R1 = 1,3,5-trimethoxy] (7.2±0.22μM and 11.80.21±μM), 2(7.10.24±μM and 9.8±0.27μM), exhibited relatively higher cytotoxic activity against both MCF7 and SKVO3 cell lines, resp.
International Research Journal of Pharmacy published new progress about Antitumor agents. 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Category: isoquinoline.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem