Li, Yingfen published the artcileOne-pot synthesis of benzimidazole-pyrazines and their anticancer activities, SDS of cas: 104-01-8, the main research area is fused benzimidazole pyrazine one pot preparation antitumor human.
The skeleton of fused benzimidazole-pyrazines I (R1 = Ph, 4-ClC6H4; R2 = Ph, CH2(4-MeOC6H4), CH2(4-ClC6H4), CH2(3,4-(Cl)2C6H3)) was constructed via an Ugi/deprotection/cyclization (UDC) and hydroamination cascade reaction. This four-step reaction was carried out in a one-pot procedure with only one-time column chromatog. purification The representative compound I (R1 = Ph; R2 = CH2(4-ClC6H4)) exhibited 67% cell growth inhibitory activity against human breast cancer cell line MDA-MB-453 at the concentration of 10μM.
Journal of Heterocyclic Chemistry published new progress about Antitumor agents. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, SDS of cas: 104-01-8.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem