41034-52-0, Name is 1,2,3,4-Tetrahydro-isoquinoline-1-carboxylic acid, belongs to isoquinoline compound, is a common compound. 41034-52-0In an article, authors is Ardill, Harriet, once mentioned the new application about 41034-52-0.
X=Y-ZH SYSTEMS AS POTENTIAL 1,3-DIPOLES. PART 19. INTRAMOLECULAR CYCLOADDITIONS OF NON-STABILISED AZOMETHINE YLIDES GENERATED VIA THE DECARBOXYLATIVE ROUTE FROM alpha-AMINO ACIDS.
Heating a range of acyclic and cyclic secondary alpha-amino acids with aryl aldehydes containing a proximate terminal alkene or alkyne results in consecutive condensation and decarboxylation, followed by intramolecular cycloaddition of the resultant non-stabilised azomethine ylides.Evidence is produced for syn-anti dipole equilibration and it is found that intramolecular cycloadditions to a terminal alkyne involve only the anti-dipole and proceed via an exotransition state to give a single cycloadduct.In contrast, intramolecular cycloaddition to a terminal alkene involves both anti- and syn-dipoles, with trapping of the former being slightly energetically preferred, resulting in mixtures of two stereoisomeric cycloadducts.Intramolecular cycloadditions of terminal alkenes to anti-dipoles proceed via exo-transition states whilst analogous reactions of the syn-dipole involve endo-transition states.
Do you like my blog? If you like, you can also browse other articles about this kind. 41034-52-0Thanks for taking the time to read the blog about 41034-52-0
Reference£º
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem