Zima, Vaclav published the artcileInvestigation of flexibility of neuraminidase 150-loop using tamiflu derivatives in influenza A viruses H1N1 and H5N1, COA of Formula: C8H11NO, the main research area is influenza A virus H1N1 H5N1 neuraminidase 150 loop antiviral; tamiflu oseltamivir crystal structure; Click chemistry; Crystal structure; Influenza neuraminidase; Oseltamivir.
This study focuses on design, synthesis and in vitro evaluation of inhibitory potency of two series of sialylmimetic that target an exosite (“”150-cavity””) adjacent to the active site of influenza neuraminidases from A/California/07/2009 (H1N1) pandemic strain and A/chicken/Nakorn-Patom/Thailand/CU-K2-2004 (H5N1). The structure-activity anal. as well as 3-D structure of the complex of parental compound with the pandemic neuraminidase p09N1 revealed high flexibility of the 150-cavity towards various modification of the neuraminidase inhibitors. Furthermore, our comparison of two methods for inhibition constant determination performed at slightly different pH values suggest that the exptl. conditions of the measurement could dramatically influence the outcome of the anal. in the compound-dependent manner. Therefore, previously reported Ki values determined at non-physiol. pH should be carefully scrutinized.
Bioorganic & Medicinal Chemistry published new progress about Antiviral agents. 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, COA of Formula: C8H11NO.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem