Delcaillau, Tristan published the artcilePalladium-Catalyzed Carbothiolation of Alkenes and Alkynes for the Synthesis of Heterocycles, Synthetic Route of 104-01-8, the main research area is oxindole thiomethyl preparation; amide alkenyl alkynyl chemoselective intramol carbothiolation palladium catalyst.
The intramol. carbothiolation of unsaturated hydrocarbons, e.g., I (R1 = Me, Et, i-Pr, cyclopentyl, Ph, etc.; R2 = Me, NCCH2, PhCH2, AcOCH2CH2, etc.; R3 = Me, 4-MeOC6H4, 2-naphthyl, 3-pyridyl, etc.), using a palladium-NHC catalyst (NHC = N-heterocyclic carbene) and giving access to a variety of heterocycles, e.g., II, is described. Herein, a single catalyst system enables both initial activation of a C(sp2)-S bond through oxidative addition and formation of a C(sp3)-S bond through a terminal reductive elimination, unlocking a completely atom-economical transfer across alkenes. The reaction tolerates a variety of different functional groups, exhibits excellent chemoselectivity in the presence of competing thioether moieties, and can be applied to various alkenes and alkynes. Furthermore, product derivatization was demonstrated to access a broad variety of sulfur-containing compounds
ACS Catalysis published new progress about Chemoselectivity. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Synthetic Route of 104-01-8.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem