Ren, Zili published the artcileConstruction of oxime ester derivatives of osthole from Cnidium monnieri, and evaluation of their agricultural activities and control efficiency, Application In Synthesis of 104-01-8, the main research area is Cnidium monnieri agricultural activity osthole oxime ester derivative; agricultural activity; natural product; osthole; oxime esters; structural modification.
In order to discover natural-product-based pesticidal candidates, a series of coumarin-like derivatives containing oxime ester fragments at the C-8 position were prepared by structural modification of osthole, a natural plant product isolated from Cnidium monnieri. Their pesticidal activities were evaluated against two typically fruit trees/crop-threatening agricultural pests, Mythimna separata Walker and Tetranychus cinnabarinus Boisduval. Osthole was regioselectively oxidized by selenium dioxide to give the E-isomer, (2′E)-3′-formaldehydylosthole (2). Four key steric structures of 2, (2′E, 4′E)-(o-chloropyrid-3-ylcarbonyl)oximinylosthole (4o), (2′E, 4′E)-(styrylcarbonyl)oximinylosthole (4t), and (2′E, 4′E)-(acetyl)oximinylosthole (4w) were undoubtedly confirmed by X-ray crystallog. Against T. cinnabarinus, it is noteworthy that (2′E, 4′E)-(p-chlorophenylcarbonyl)oximinylosthole (4c) exhibited over three-fold more potent acaricidal activity of the precursor osthole, with especially good control efficiency observed in the glasshouse. Against M. separata, compounds 4c and (2′E, 4′E)-(p-nitrophenylcarbonyl)oximinylosthole (4f) showed the most pronounced growth inhibitory activity. The relationships between their structures and agricultural activities also were studied. These results demonstrate that compound 4c could be further structurally modified as pesticidal agents. It will lay the foundation for future application of osthole derivatives as pesticides.
Pest Management Science published new progress about Acaricides. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Application In Synthesis of 104-01-8.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem