Alsaif, Nawaf A. published the artcileSynthesis of novel diclofenac hydrazones: molecular docking, anti-inflammatory, analgesic and ulcerogenic activity, Formula: C9H10O3, the main research area is dichloroanilinophenyl methylidene acetohydrazide preparation antiinflammatory analgesic ulcerogenic SAR docking.
This study was aimed to design novel diclofenac hydrazones I [R = 2,4-dimethoxyphenyl, 3,5-dimethoxy-4-hydroxyphenyl, 2,5-dihydroxyphenyl, Etc] having anti-inflammatory and analgesic activity with gastric sparing effect. A new series of 2-[2-(2,6-dichloroanilino)phenyl]-N’-[(substituted phenyl)methylidene] acetohydrazide derivatives I were synthesized and evaluated for their anti-inflammatory, analgesic, and ulcerogenic activity. The compounds I were identified and confirmed by elemental anal. and spectral data. During anti-inflammatory activity by carrageenan-induced paw edema method, compounds I [R = 2,3-dimethoxyphenyl, 2,4-dimethoxyphenyl, 3-ethoxy-2-hydroxyphenyl, 3,5-dimethoxy-4-hydroxyphenyl, 3-methoxy-4-ethoxyphenyl, 2,5-dihydroxyphenyl] were found to be most promising. Compounds I [R = 2,4-dimethoxyphenyl, 3,5-dimethoxy-4-hydroxyphenyl, 2,5-dihydroxyphenyl] have been found to have significant analgesic activity compared to the reference drug diclofenac in analgesic activity by both the hot plate method and acetic acid-induced writhing method. The compounds I which presented highly significant anti-inflammatory and analgesic activity were further tested for their ulcerogenic activity. Compounds I [R = 2,4-dimethoxyphenyl, 3,5-dimethoxy-4-hydroxyphenyl] showed maximum ulcerogenic reduction activities. Compound I [R = 3,5-dimethoxy-4-hydroxyphenyl] was found to have LD50 of 168 mg/kg. Compound I [R = 3,5-dimethoxy-4-hydroxyphenyl] with 3,5-dimethoxy-4-hydroxyphenyl substitution was found to be the most promising anti-inflammatory and analgesic agent with gastric sparing activity. Mol. docking of compounds I was performed for COX-1/COX-2 binding site. Lead compound I [R = 3,5-dimethoxy-4-hydroxyphenyl] showed better binding affinities of -9.4 kJ/mol with both COX-1 and COX-2 as compared to the standard drug, diclofenac with binding affinities of -6.6 kJ/mol and -8.1 kJ/mol for COX-1 and COX-2, resp.
Journal of Chemistry published new progress about Analgesics. 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Formula: C9H10O3.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem