Wasilewski, Tomasz published the artcileDetermination of long-chain aldehydes using a novel quartz crystal microbalance sensor based on a biomimetic peptide, HPLC of Formula: 1205-17-0, the main research area is aliphatic aldehyde quartz crystal microbalance biosensor biomimetic peptide.
This study presents investigation on usefulness of the peptide mimicking HarmOBP7 region as a receptor element of the piezoelec. sensor for selective anal. of long-chain aldehydes. Identification of odorant binding proteins creates new possibilities for design of peptides mimicking binding properties of their volatile compounds Exploration of OBPs and new peptide sequences capable to effectively bind volatile compounds is necessary to enhance artificial olfaction. For the development of biosensors where simple detection is crucial rather than identification of subsequent metabolic activity, the use of sub-protein components (e.g. ligand-binding regions or synthetic peptides) is still escalating. Bearing all this in mind, a segment of a peptide sequence associated with a specific function of HarmOBP7 (involved in binding the long-chain aldehydes) has been designed, synthesized and immobilized on a piezoelec. transducer. The results of in silico investigations were correlated with the exptl. measurements of gas substances. The correlated results confirm a high selectivity of the KLLFDSLTDLKKKMSEC-based sensor with respect to long-chain aliphatic aldehydes including octanal, decanal, undecanal, nonanal and helional. Odorant mols. interact with recognition peptide with specific affinities. The results can throw a new light on the possibility of synthetic peptide application as a receptor layer in biosensors in odorants anal.
Microchemical Journal published new progress about Biomarkers. 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, HPLC of Formula: 1205-17-0.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem