Alfinito, Eleonora published the artcileHuman olfactory receptor 17-40 as an active part of a nanobiosensor: a microscopic investigation of its electrical properties, Safety of 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, the main research area is human olfactory receptor nanobiosensor elec resistance impedance spectrum.
Increasing attention has recently been devoted to protein-based nanobiosensors. The main reason is the huge number of possible technol. applications, ranging from drug detection to early cancer diagnosis. Their operating model is based on protein activation and the corresponding conformational change due to the capture of an external mol., the so-called ligand. Recent measurements, performed with different techniques on the human 17-40 olfactory receptor, revealed a very narrow window of response in respect to the odor concentration This is a crucial point for understanding whether the use of this olfactory receptor as a sensitive part of a nanobiosensor is a good choice. In this paper we investigate the topol. and elec. properties of the human olfactory receptor 17-40 with the objective of providing a microscopic interpretation of available experiments To this purpose, we model the protein by means of a graph that is able to capture the mean features of the 3D backbone structure. The graph is then associated with an equivalent impedance network, able to evaluate the impedance spectra of the olfactory receptor in its native and activated state. We assume a topol. origin of the different protein elec. responses to different ligand concentrations: In this perspective all the exptl. data are collected and interpreted satisfactorily within a unified scheme, also useful for application to other proteins.
RSC Advances published new progress about Biosensors. 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Safety of 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem