With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6624-49-3,Isoquinoline-3-carboxylic acid,as a common compound, the synthetic route is as follows.
A solution of 70 (30 mg, 0.13 mmol, leq) and triethylamine (0.65 mmol, 5 eq.) in THF (2 mL) was added to a solution of commercially available isoquinoline-3-carboxylic acid (22 mg, 0.13 mmol) and HATU (50 mg, 0.13 mmol) in THF (2 mL). The reaction was stirred for 3h at 60¡ãC, then cooled to room temperature and poured into water-ice. The product was extracted with EtOAc, dried (MgS04), filtered and concentrated. The crude product was purified by column chromatography on silica gel (ethyl acetate-hexanes) to afford the product as a white powder in 39percent yield; mp 228-230 ¡ãC. XH NMR (400 MHz, DMSO-i?) delta 11.99 (s, 2H), 9.51 (s, 1H), 8.77 (s, 1H), 8.34 (d, J= 7.33 Hz, 1H), 8.29 (d, J= 8.06 Hz, 1H), 7.87 – 7.99 (m, 2H), 7.66 (s, 1H), 7.56 (d, J= 2.01 Hz, 1H), 7.53 (dd, J= 1.92, 8.33 Hz, 1H), 7.03 (d, J= 8.42 Hz, 1H), 3.85 (s, 3H), 3.80 (s, 3H); LCMS (ESI) m/z 392 (MH+)
The synthetic route of 6624-49-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; RENSLO, Adam R.; GALLARDO-GODOY, Alejandra; SILBER, B. Michael; PRUSINER, Stanley B.; GILES, Kurt; LI, Zhe; NEITZ, R. Jeffrey; WO2013/33037; (2013); A2;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem