The swamping catalyst effect. VI. The halogenation of isoquinoline and quinoline was written by Gordon, Marshall;Pearson, D. E.. And the article was included in Journal of Organic Chemistry in 1964.Recommanded Product: 90721-35-0 This article mentions the following:
Halogenation of the aluminum chloride complexes of isoquinoline or quinoline gave in good yield halogen derivatives substituted in the benzenoid ring. Bromination of the aluminum chloride-isoquinoline complex gave the following sequence in substitution: 5-bromo-, 5,8-dibromo-, 5,7,8-tribromo-. To obtain good yields of 5,7,8-tribromoisoquinoline, it was necessary to brominate 5,8-dibromoisoquinoline, not isoquinoline itself. Bromination of the aluminum chloride complex of quinoline gave similar results except that 5,6,8-tribromoquinoline was obtained by bromination of 5,8-dibromoquinoline. Chlorination of the aluminum chloride complexes of both quinoline and isoquinoline gave results very similar to bromination. 5,6,7,8-Tetrabromo- and 5,6,7,8-tetrachloroquinoline were isolated also. Identification of many of these compounds was carried out by synthesis from known compounds In the experiment, the researchers used many compounds, for example, 5-Bromoisoquinolin-8-amine (cas: 90721-35-0Recommanded Product: 90721-35-0).
5-Bromoisoquinolin-8-amine (cas: 90721-35-0) belongs to isoquinoline derivatives. Although isoquinoline derivatives can be synthesized by several methods, relatively few direct methods deliver the unsubstituted isoquinoline. Isoquinoline-type alkaloids show biological activities similar to those of morphinane-, protoberberine-, and benzophenanthridine-type alkaloids.Recommanded Product: 90721-35-0
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem