Syntheses of hydrogenated quinolines and isoquinolines as analgesics. X. Oxidation of alkylpyridines was written by Sugimoto, Norio;Kugita, Hiroshi;Tanaka, Tadashi. And the article was included in Yakugaku Zasshi in 1956.Application of 135311-97-6 This article mentions the following:
Oxidation of 2- (I), 3- (II) and 4-EtC5H4N (III) and the 1-oxides with CrO3 effected oxidation in the order of II > III > I to the corresponding AcC5H4N in 50-15% yield. Oxidation of 15 g. 5,6,7,8-tetrahydroisoquinoline in 80 ml. AcOH and 30 g. concentrated H2SO4 at 10-5° with 16 g. CrO3 in 9 ml. water and 45 ml. AcOH by keeping overnight, removing the AcOH in vacuo, alkalifying with NaOH and extracting with Et2O yielded 8-oxo- (IV), b4 123-4°, and 5-oxo-5,6,7,8-tetrahydroisoquinoline (V), b4 113-15°, in 2:1 ratio; IV.HCl, m. 227-9°, and V.HCl, m. 235-6°. In the experiment, the researchers used many compounds, for example, 6,7-Dihydroisoquinolin-8(5H)-one hydrochloride (cas: 135311-97-6Application of 135311-97-6).
6,7-Dihydroisoquinolin-8(5H)-one hydrochloride (cas: 135311-97-6) belongs to isoquinoline derivatives. Quinoline is a catabolite of tryptophan, the basic structure of some antihypertensive drugs, such as the peripheral vasodilators prazosin and doxazosin. It protonates to form salts upon treatment with strong acids, such as HCl. It forms adducts with Lewis acids, such as BF3.Application of 135311-97-6
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem