Electronic effects in isoquinoline systems was written by Zielinski, Wojciech;Kudelko, Agnieszka;Mazik, Monika. And the article was included in Polish Journal of Applied Chemistry in 1995.Category: isoquinoline This article mentions the following:
Values of pKa for 1-(N,N-dimethylamino)-3-methylisoquinoline and a series of their 6- and 7-substituted derivatives, 3-methylisoquinoline and 1-amino-3-methylisoquinoline were determined in 50% volume/volume aqueous-methanolic solution by the spectrophotometric method. The determined values of pKa and values of pKa for 1-phenyl-3-methylisoquinolines and 1,3-dimethylisoquinolines taken from literature were correlated with the Hammett σ constants Good correlations were obtained for 6-substituted derivatives with σp constants and for 7-substituted derivatives with σm constants The electronic effects occurring in the studied isoquinoline systems made by substituents present in pyridine and benzene ring are discussed basing on the determined values. In the experiment, the researchers used many compounds, for example, Isoquinolin-7-amine (cas: 23707-37-1Category: isoquinoline).
Isoquinolin-7-amine (cas: 23707-37-1) belongs to isoquinoline derivatives. Quinoline is a mancude organic heterobicyclic parent, an azaarene, an ortho-fused heteroarene and a member of isoquinolines. The Pomeranz–Fritsch reaction provides a method for the preparation of isoquinoline. This reaction uses a benzaldehyde and aminoacetoaldehyde diethyl acetal, which in an acid medium react to form isoquinoline.Category: isoquinoline
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem