Lee, Hobin et al. published their research in European Journal of Medicinal Chemistry in 2019 | CAS: 23707-37-1

Isoquinolin-7-amine (cas: 23707-37-1) belongs to isoquinoline derivatives. Being an analog of pyridine, isoquinoline is a weak base, with a pKa of 5.14. They are also used to make oil-soluble dyes, food colorants, pharmaceuticals, pH indicators and other organic compounds. Quality Control of Isoquinolin-7-amine

Discovery of dual-acting opioid ligand and TRPV1 antagonists as novel therapeutic agents for pain was written by Lee, Hobin;Ahn, Songyeon;Ann, Jihyae;Ha, Heejin;Yoo, Young Dong;Kim, Young Ho;Hwang, Ji-Young;Hur, Kwang-Hyun;Jang, Choon-Gon;Pearce, Larry V.;Esch, Timothy E.;Lewin, Nancy E.;Blumberg, Peter M.;Lee, Jeewoo. And the article was included in European Journal of Medicinal Chemistry in 2019.Quality Control of Isoquinolin-7-amine This article mentions the following:

In order to discover a novel type of analgesic, dual activity ligands with TRPV1 antagonism and mu-opioid receptor affinity were investigated with the goal of eliciting synergistic analgesia while avoiding the side effects associated with single targeting. Based on a combination approach, a series of 4-benzyl-4-(dimethylamino)piperidinyl analogs I (R = 2,3-dihydrobenzofuran-6-yl, isoquinolin-8-yl, quinolin-5-yl, etc., R1 = NH, HCCH3) were designed, synthesized and evaluated for their receptor activities. Among them, compound I (R = quinolin-5-yl) exhibited the most promising dual-acting activity toward TRPV1 and the mu-opioid receptor in vitro. In vivo, compound I (R = quinolin-5-yl) displayed potent, dose-dependent antinociceptive activity in both the 1st and 2nd phases in the formalin assay. Consistent with its postulated mechanism, it was confirmed that in vivo, as in vitro, compound I (R = quinolin-5-yl) both antagonized TRPV1 and functioned as a mu-opioid agonist. This result indicates that dual-acting TRPV1 antagonist/mu-opioid ligands can be made and represent a new and promising class of analgesic. In the experiment, the researchers used many compounds, for example, Isoquinolin-7-amine (cas: 23707-37-1Quality Control of Isoquinolin-7-amine).

Isoquinolin-7-amine (cas: 23707-37-1) belongs to isoquinoline derivatives. Being an analog of pyridine, isoquinoline is a weak base, with a pKa of 5.14. They are also used to make oil-soluble dyes, food colorants, pharmaceuticals, pH indicators and other organic compounds. Quality Control of Isoquinolin-7-amine

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem