An efficient and facile strategy for trifluoromethylation and perfluoroalkylation of isoquinolines and heteroarenes was written by Pan, Yang;Li, Jiangtao;Li, Zhefeng;Huang, Feng;Ma, Xiaofeng;Jiao, Wei;Shao, Huawu. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020.Name: 4-Methoxyisoquinoline This article mentions the following:
An effective and regioselective strategy for trifluoromethylation and perfluoroalkylation of isoquinolines I (R1 = OMe, Ph, Br, etc.; R2 = H, formyl, OMe, NO2; R3 = Me, 2-phenylethynyl, Cl, etc.; R4 = H, OMe; R5 = H, Ph, Br) and heteroarenes R6H (R6 = phenanthridin-6-yl, thieno[2,3-c]pyridin-7-yl, quinazolin-2-yl, etc.) was developed. By combination of TMSCnF2n+1 (n = 1, 2, 3) with PIFA, the method achieved the corresponding perfluoroalkylated products R6CnF2n+1 (n = 1, 2, 3) with broad functional group tolerance. In the experiment, the researchers used many compounds, for example, 4-Methoxyisoquinoline (cas: 36034-54-5Name: 4-Methoxyisoquinoline).
4-Methoxyisoquinoline (cas: 36034-54-5) belongs to isoquinoline derivatives. Quinoline and isoquinoline skeletons are among the most attractive frameworks with a wide range of biological and pharmacological activities. The Pomeranz–Fritsch reaction provides a method for the preparation of isoquinoline. This reaction uses a benzaldehyde and aminoacetoaldehyde diethyl acetal, which in an acid medium react to form isoquinoline.Name: 4-Methoxyisoquinoline
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem