Plasma metabolomics-based reveals the treatment mechanism of ShenGui capsule for application to coronary heart disease in a rat model was written by Wang, Dan;Guo, Jialin;Liu, Tiantian;Zhou, Xinfeng;Yang, Zijun;Shi, Chang;Wang, Weiting;Li, Rongshan;Zhang, Yanwen;Junzhang;Yan, Jiuxing;Zhu, Xuehui;Li, Ying;Gong, Min;Cui, Yan;Wu, Xiaohui. And the article was included in Analytical Biochemistry in 2022.HPLC of Formula: 27104-73-0 This article mentions the following:
Shen Gui capsule (SGC) has been demonstrated to have a significant treatment effect for coronary heart disease (CHD). Nevertheless, the holistic therapeutic mechanism of SGC in vivo remain poorly interpreted. To systematically explore the preventive effect and mechanism of SGC on CHD rats using plasma metabolomics strategy. Rat CHD model was established by left anterior descending coronary artery ligation (LAD). Echocardiog, histol. analyses of the myocardium and biochem. assays on serum were used to confirm the successful establishment of the CHD model and therapeutic effects of SGC. Then, UHPLC-MS/MS-based plasma metabolomics was combined with multivariate data anal. to screen potential pharmaco biomarkers associated with SGC treatment in the LAD-induced rat CHD model. After SGC treatment, 12 abnormal metabolites considered as potiential pharmaco biomarkers recovered to near normal levels. These biomarkers were involved in several metabolic pathways, including fat and protein metabolism, phenylalanine metabolism, neuroactive ligand-receptor interaction, androgen receptor signaling pathway, and estrone metabolism These suggested that SGC achieves therapeutic action on CHD via regulating various aspects of the body such as energy metabolism, neurol. disturbances and inflammation, and thus plays a significant role in the treatment of CHD and its complications. The useful to systematically understand and analyze the mechanism of SGCs multipie pathways, multiple levels, multiple targets prevention and treatment of CHD. In the experiment, the researchers used many compounds, for example, Methyl isoquinoline-3-carboxylate (cas: 27104-73-0HPLC of Formula: 27104-73-0).
Methyl isoquinoline-3-carboxylate (cas: 27104-73-0) belongs to isoquinoline derivatives. Quinoline and isoquinoline skeletons are among the most attractive frameworks with a wide range of biological and pharmacological activities. Isoquinoline-type alkaloids show biological activities similar to those of morphinane-, protoberberine-, and benzophenanthridine-type alkaloids.HPLC of Formula: 27104-73-0
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem