Determination of homopiperazine in fasudil hydrochloride by ion chromatography was written by Chen, Mei-lan;Zhang, Ting-ting;Ye, Ming-li;Huang, Qiao-qiao;Hu, Zhong-yang;Pan, Guang-wen. And the article was included in Yaowu Fenxi Zazhi in 2013.Recommanded Product: 105628-07-7 This article mentions the following:
A new method for the determination of homopiperazine in fasudil hydrochloride based on high-performance ion chromatog. was established. Fasudil hydrochloride was first dissolved in methane sulfonic acid, and then the solution was filtered through a 0.45 μm syringe membrane filter and Guard RP cleanup column before injection. The IC separation was performed on an IonPac CS17 (4 mm × 250 mm) column with 17 mmol · L-1 methanesulfonic acid and acetonitrile (85:15) as the elution and a Cation MicroMembrane Suppressor (CMMS 300, 4 mm) as the suppression. The background was much reduced and the sensitivities of homopiperazine were greatly improved. Calibration curves of peak area vs. concentration showed a linear correlation coefficient of 0.9996 for homopiperazine in the range of 0.05-10 μg · mL-1. Average recoveries were between 98.0%-102.0%. The established Ion chromatog. method has the advantages of high sensitivity, specificity and reproductivity, which can be applied to the limit amount determination of drug homopiperazine. In the experiment, the researchers used many compounds, for example, 5-((1,4-Diazepan-1-yl)sulfonyl)isoquinoline hydrochloride (cas: 105628-07-7Recommanded Product: 105628-07-7).
5-((1,4-Diazepan-1-yl)sulfonyl)isoquinoline hydrochloride (cas: 105628-07-7) belongs to isoquinoline derivatives. Quinoline and its derivatives are widely used as fungicides, biological agents, antibiotics, alkaloids, dyes, rubber chemicals and flavoring agents. They are also used to make oil-soluble dyes, food colorants, pharmaceuticals, pH indicators and other organic compounds. Recommanded Product: 105628-07-7
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem