Synthesis and study of substituted amides of isoquinoline-3- and isoquinoline-1-carboxylic acids as potential anticonvulsants was written by Strupinska, Marzanna;Rostafinska-Suchar, Grazyna;Jakubowicz, Bartlomiej;Klimkiewicz, Paulina;Lal, Ewelina;Oczkowski, Mateusz;Prochniak, Ewa;Pirianowicz-Chaber, Elzbieta;Mazurek, Aleksander P.. And the article was included in Acta Poloniae Pharmaceutica in 2017.Reference of 486-73-7 This article mentions the following:
Previously obtained benzylamides of isoquinoline-3-carboxylic acids and isoquinoline-1-carboxylic acids exhibited anticonvulsant activity. In search for more effective anticonvulsants, a series of amides of isoquinoline- 3- and isoquinoline-1-carboxylic acids have been synthesized (1-9). The obtained compounds were evaluated qual. for their anticonvulsant activity in the maximal electroshock seizure test (MES test), minimal clonic seizure test (6Hz test) and s.c. metrazol seizure threshold test (s.c. MET test) as well as in the rotorod neurotoxicity test (Tox test). One selected compound was tested quant. in 6Hz-test in mice after i.p. administration and showed activity ED50 = 385.69 mg/kg and TD50 > 600 mg/kg (1). In the experiment, the researchers used many compounds, for example, Isoquinoline-1-carboxylic acid (cas: 486-73-7Reference of 486-73-7).
Isoquinoline-1-carboxylic acid (cas: 486-73-7) belongs to isoquinoline derivatives. Although isoquinoline derivatives can be synthesized by several methods, relatively few direct methods deliver the unsubstituted isoquinoline. Lewis acid activation and nucleophilic attack can produce multiple regioisomers in quinolines and pyridines; isoquinolines generally only undergo attack at the 1-position.Reference of 486-73-7
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem