Fast Amide Couplings in Water: Extraction, Column Chromatography, and Crystallization Not Required was written by Sharma, Sudripet;Buchbinder, Nicklas W.;Braje, Wilfried M.;Handa, Sachin. And the article was included in Organic Letters in 2020.Related Products of 486-73-7 This article mentions the following:
In the micelle of PS-750-M, the presence of 3° amides from the surfactant proline linker mimics DMF, dimethylacetamide, and N-methyl-2-pyrrolidone. The resultant micellar properties enable extremely fast amide couplings mediated by 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide (without hydroxybenzotriazole), rather than expensive and specialized coupling agents. Conditions have been developed wherein products precipitate, and isolation by filtration completely avoids the use of organic solvent. This methodol. is scalable and avoids product epimerization. In the experiment, the researchers used many compounds, for example, Isoquinoline-1-carboxylic acid (cas: 486-73-7Related Products of 486-73-7).
Isoquinoline-1-carboxylic acid (cas: 486-73-7) belongs to isoquinoline derivatives. Isoquinoline is a structural isomer of quinoline, which have antiseptic, antipyretic and anti-cyclic properties, and can be used as antimalarial drugs and for the preparation of other antimalarial medicine. Lewis acid activation and nucleophilic attack can produce multiple regioisomers in quinolines and pyridines; isoquinolines generally only undergo attack at the 1-position.Related Products of 486-73-7
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem