One substrate, two modes of C-H functionalization: a metal-controlled site-selectivity switch in C-H arylation reactions was written by Tiwari, Virendra Kumar;Kamal, Neha;Kapur, Manmohan. And the article was included in Organic Letters in 2017.Reference of 607-32-9 This article mentions the following:
Ruthenium-catalyzed oxidative arylation of 2-acylisoquinolines with arylboronic acids in the presence of copper(II) triflate-O2 oxidant and AgSbF6 or carboxylic acid additive results in C3-H activation and formation of 3-arylisoquinolines, the regioselectivity opposite to previously reported C4 selectivity in palladium-catalyzed reaction. A unique site-selectivity switch has been achieved in the ruthenium-catalyzed C-H arylation reaction of N-acetyl-1,2-dihydroisoquinolines. This metal-mediated switch is antipodal to the previous report on the palladium-mediated C-4 C-H arylation on the same substrate. Mechanistic details reveal interesting aspects of the reaction pathway, and kinetic studies bring out the difference in the modes of C-H activation adopted by the two catalytic systems. In the experiment, the researchers used many compounds, for example, 5-Nitroisoquinoline (cas: 607-32-9Reference of 607-32-9).
5-Nitroisoquinoline (cas: 607-32-9) belongs to isoquinoline derivatives. Quinoline and isoquinoline skeletons are among the most attractive frameworks with a wide range of biological and pharmacological activities. They are also used to make oil-soluble dyes, food colorants, pharmaceuticals, pH indicators and other organic compounds. Reference of 607-32-9
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem