Visible-Light Photoredox Alkylation of Heteroaromatic Bases Using Ethyl Acetate as Alkylating Agent was written by Gyorfi, Nandor;Kotschy, Andras;Gyuris, Mario. And the article was included in European Journal of Organic Chemistry in 2020.COA of Formula: C11H9NO2 This article mentions the following:
An efficient room-temperature visible-light photoredox α-acyloxyalkylation reaction of N-heteroarenes is reported, which relies on the use of Et acetate as a cheap and non-conventional radical source. The direct C(sp2)-C(sp3) coupling was extended to a diverse set of mono-, bi-, and tricyclic of N-heteroaromatics, and the optimized photoredox protocol was successfully performed on a multigram scale. The scope of the alkylating agent was also explored and a plausible mechanism was proposed, involving photoinduced single-electron transfer and hydrogen-atom transfer processes. In the experiment, the researchers used many compounds, for example, Methyl isoquinoline-3-carboxylate (cas: 27104-73-0COA of Formula: C11H9NO2).
Methyl isoquinoline-3-carboxylate (cas: 27104-73-0) belongs to isoquinoline derivatives. Being an analog of pyridine, isoquinoline is a weak base, with a pKa of 5.14. Lewis acid activation and nucleophilic attack can produce multiple regioisomers in quinolines and pyridines; isoquinolines generally only undergo attack at the 1-position.COA of Formula: C11H9NO2
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem