Minisci C-H alkylation of N-heteroarenes with aliphatic alcohols via β-scission of alkoxy radical intermediates was written by Hu, Xiafei;Li, Guo-Xing;He, Gang;Chen, Gong. And the article was included in Organic Chemistry Frontiers in 2019.Product Details of 105628-07-7 This article mentions the following:
A Minisci-type C-H alkylation reaction of N-heteroarenes with aliphatic alcs. via β-scission of alkoxy radical intermediates under photoredox-catalyzed conditions was developed. The use of the benziodoxole acetate (BI-OAc) oxidant is critical to achieving high efficiency under mild conditions using a slight excess of an alc. reactant. Primary, secondary and tertiary alcs. all are compatible. Reactions of various complex N-heteroarenes including drug mols. and steroid natural products were demonstrated. In the experiment, the researchers used many compounds, for example, 5-((1,4-Diazepan-1-yl)sulfonyl)isoquinoline hydrochloride (cas: 105628-07-7Product Details of 105628-07-7).
5-((1,4-Diazepan-1-yl)sulfonyl)isoquinoline hydrochloride (cas: 105628-07-7) belongs to isoquinoline derivatives. Quinoline and isoquinoline skeletons are among the most attractive frameworks with a wide range of biological and pharmacological activities. The Pomeranz–Fritsch reaction provides a method for the preparation of isoquinoline. This reaction uses a benzaldehyde and aminoacetoaldehyde diethyl acetal, which in an acid medium react to form isoquinoline.Product Details of 105628-07-7
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem