Asymmetric Transfer Hydrogenation in Thermomorphic Microemulsions Based on Ionic Liquids was written by Hejazifar, Mahtab;Palvoelgyi, Adam Mark;Bitai, Jacqueline;Lanaridi, Olga;Bica-Schroeder, Katharina. And the article was included in Organic Process Research & Development in 2019.Electric Literature of C15H13N This article mentions the following:
A thermomorphic ionic-liquid-based microemulsion system was successfully applied for the Ru-catalyzed asym. transfer hydrogenation of ketones. On the basis of the temperature-dependent multiphase behavior of the targeted microemulsion, simple product separation as well as catalyst recycling could be realized. The use of water-soluble ligands improved the immobilization of the catalyst in the microemulsion phase and significantly decreased the catalyst leaching into the organic layer upon extraction of the product. Eventually, the optimized microemulsion system could be applied to a wide range of aromatic ketones that were reduced with good isolated yields (up to 98%) and enantioselectivities (up to 97%), while aliphatic ketones were less successful. In the experiment, the researchers used many compounds, for example, 1-Phenyl-3,4-dihydroisoquinoline (cas: 52250-50-7Electric Literature of C15H13N).
1-Phenyl-3,4-dihydroisoquinoline (cas: 52250-50-7) belongs to isoquinoline derivatives. Being an analog of pyridine, isoquinoline is a weak base, with a pKa of 5.14. Most traditional methods of generating isoquinoline do so via oxidative aromatization of dihydro- or tetrahydro-isoquinolines, usually offering some environmental or economic advantage.Electric Literature of C15H13N
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem