Discovery of Q-markers of Wenxin Formula based on a Chinmedomics strategy was written by Wang, Zong-wei;Liu, Chang;Zhang, Ai-hua;Yan, Guang-li;Sun, Hui;Han, Ying;Ma, Wei-tong;Wang, Xi-jun. And the article was included in Journal of Ethnopharmacology in 2022.Related Products of 2086-83-1 This article mentions the following:
Wenxin Formula (WXF) is a well-known prescription with a significant curative effect in the treatment of cardiac disease. However, the lack of quality control standards caused by unclear quality control components limits the development of new drugs. The aims of this research were to discover the effective materials and screen the quality markers of WXF through a chinmedomics strategy to aid in efficacy evaluation. The therapeutic effect of WXF against myocardial ischemia (MI) was evaluated by serum metabolic profiling combined with routine electrocardiog.; analyses of the serum biochem. indexes CK, CK-MB and α-HBDH; and histopathol. tests involving TTC staining and HE staining. The raw data of serum samples were obtained by UPLC-HDMS, and multivariate statistical anal. was performed with Progenesis QI software. PCMS software was used to sift the quality markers of WXF. A total of 25 metabolites were characterized as biomarkers for myocardial ischemia, and Wenxin Formula reversed the levels of 23 of them that were involved in arachidonic acid metabolism, glycerophospholipid metabolism, lysine degradation, and tyrosine metabolism Eight constituents absorbed into blood were considered to form the effective material basis of Wenxin Formula for treating myocardial ischemia, and the Q-markers selected through PCMS were ginsenoside Rb1, cinnamic acid, paeoniflorin and berberine. WXF significantly ameliorated the clin. symptoms, pathol. changes and metabolic abnormalities of myocardial ischemia. This study shows that chinmedomics is a powerful strategy to filter Q-markers from effective constituents to rationally evaluate the efficacy and safety of TCMs. In the experiment, the researchers used many compounds, for example, 9,10-Dimethoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium (cas: 2086-83-1Related Products of 2086-83-1).
9,10-Dimethoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium (cas: 2086-83-1) belongs to isoquinoline derivatives. Quinoline and isoquinoline skeletons are among the most attractive frameworks with a wide range of biological and pharmacological activities. Most traditional methods of generating isoquinoline do so via oxidative aromatization of dihydro- or tetrahydro-isoquinolines, usually offering some environmental or economic advantage.Related Products of 2086-83-1
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem