Aryne triggered dearomatization reaction of isoquinolines and quinolines with chloroform was written by Tan, Jiajing;Liu, Binbin;Su, Shuaisong. And the article was included in Organic Chemistry Frontiers in 2018.Synthetic Route of C9H6IN This article mentions the following:
The direct dearomatization reaction of isoquinolines and quinolines with chloroform has been accomplished through in situ electrophilic aryne activation and nucleophile formation. This transition metal-free protocol shows a broad scope of substrates, providing consistently high yields of medicinally-important dihydro(iso)quinoline derivatives The utility of this method has been further demonstrated in the synthesis of deuterated analogs. In the experiment, the researchers used many compounds, for example, 4-Iodoisoquinoline (cas: 55270-33-2Synthetic Route of C9H6IN).
4-Iodoisoquinoline (cas: 55270-33-2) belongs to isoquinoline derivatives. Isoquinoline is a structural isomer of quinoline, which have antiseptic, antipyretic and anti-cyclic properties, and can be used as antimalarial drugs and for the preparation of other antimalarial medicine. The Pomeranz–Fritsch reaction provides a method for the preparation of isoquinoline. This reaction uses a benzaldehyde and aminoacetoaldehyde diethyl acetal, which in an acid medium react to form isoquinoline.Synthetic Route of C9H6IN
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem