In silico analysis of the molecular interaction and bioavailability properties between some alkaloids and human serum albumin was written by Sadeghi, Morteza;Miroliaei, Mehran;Taslimi, Parham;Moradi, Mohammad. And the article was included in Structural Chemistry in 2022.Safety of 9,10-Dimethoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium This article mentions the following:
Human serum albumin (HSA) is an important carrier protein in plasma with various functions, and it is exposed to glycation. Alkaloids are diverse compounds that have showed different anti-glycation activities. The present study aimed to investigate the anti-glycation activity of thirty alkaloid compounds First, the compounds were studied via Lipinski鈥瞫 rule; then, among thirty alkaloids, twenty-three were further designated for docking study, using AutoDock program. Three compounds which provided the min. docking score were selected for further assays. Jatrorrhizine displayed potential activity to inhibit the HSA glycation. The stability of the jatrorrhizine-HSA complex was confirmed by mol. dynamics simulation (MDs). To approve the efficacy of this compound, future in vitro and in vivo studies are required. In the experiment, the researchers used many compounds, for example, 9,10-Dimethoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium (cas: 2086-83-1Safety of 9,10-Dimethoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium).
9,10-Dimethoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium (cas: 2086-83-1) belongs to isoquinoline derivatives. Quinoline is a catabolite of tryptophan, the basic structure of some antihypertensive drugs, such as the peripheral vasodilators prazosin and doxazosin. Other industrial applications include their use as corrosion inhibitors, preservatives, and as solvents for resins and terpenes.Safety of 9,10-Dimethoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem