Regioselective Cyanation of Six-Membered N-Heteroaromatic Compounds Under Metal-, Activator-, Base- and Solvent-Free Conditions was written by Sarmah, Bikash Kumar;Konwar, Monuranjan;Bhattacharyya, Dipanjan;Adhikari, Priyanka;Das, Animesh. And the article was included in Advanced Synthesis & Catalysis in 2019.Recommanded Product: 607-32-9 This article mentions the following:
A regioselective cyanation of heteroaromatic N-oxides with trimethylsilyl cyanide was developed to obtain 2-substituted N-heteroaromatic nitriles without the requirement of any external activator-, metal-, base- and solvent. The present protocol was a straightforward, one-pot heteroaromatic C-H cyanation process and proceeded smoothly in conventional heating but also under microwave irradiation with shorter reaction times. This approach now allowed access to a broad class of quinoline N-oxides and other heteroarene N-oxides with high to good yields and can also be scaled up to obtain gram quantities. Further application of this process was observed and utilized in late-stage cyanation of the anti-malarial drug quinine as well as transformation of the 2-cyanoazines to a series of biol. important mols. Based on the exptl. observations, a plausible mechanism was also proposed highlighting the dual role of trimethylsilyl cyanide as a nitrile source and as an activating agent. In the experiment, the researchers used many compounds, for example, 5-Nitroisoquinoline (cas: 607-32-9Recommanded Product: 607-32-9).
5-Nitroisoquinoline (cas: 607-32-9) belongs to isoquinoline derivatives. Quinoline and its derivatives are widely used as fungicides, biological agents, antibiotics, alkaloids, dyes, rubber chemicals and flavoring agents. Isoquinoline-type alkaloids show biological activities similar to those of morphinane-, protoberberine-, and benzophenanthridine-type alkaloids.Recommanded Product: 607-32-9
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem