Iridium-catalyzed asymmetric hydrogenation of cyclic iminium salts was written by Ji, Yue;Feng, Guang-Shou;Chen, Mu-Wang;Shi, Lei;Du, Haifeng;Zhou, Yong-Gui. And the article was included in Organic Chemistry Frontiers in 2017.Application of 52250-50-7 This article mentions the following:
An enantioselective hydrogenation of cyclic iminium salts has been successfully realized by employing [Ir(COD)Cl]2 and chiral diphosphine ligands as catalyst, furnishing chiral N-alkyl tetrahydroisoquinolines and N-alkyl tetrahydro-尾-carbolines with up to 96% ee and 88% ee, resp. The hydrogenation provides a direct, simple and efficient protocol toward chiral tertiary amines. Meanwhile, asym. hydrogenation at the gram scale was also conducted smoothly without loss of reactivity and enantioselectivity. In the experiment, the researchers used many compounds, for example, 1-Phenyl-3,4-dihydroisoquinoline (cas: 52250-50-7Application of 52250-50-7).
1-Phenyl-3,4-dihydroisoquinoline (cas: 52250-50-7) belongs to isoquinoline derivatives. Being an analog of pyridine, isoquinoline is a weak base, with a pKa of 5.14. Isoquinoline-type alkaloids show biological activities similar to those of morphinane-, protoberberine-, and benzophenanthridine-type alkaloids.Application of 52250-50-7
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem