N-alkylation of 2-pyridone derivatives via palladium(II)-catalyzed directed alkene hydroamination was written by Gurak, John A. Jr.;Tran, Van T.;Sroda, Miranda M.;Engle, Keary M.. And the article was included in Tetrahedron in 2017.Recommanded Product: 491-30-5 This article mentions the following:
A selective N-alkylation reaction of 2-pyridones and related heterocycles via intermol. alkene hydroamination is reported. The reaction utilizes palladium(II) acetate as a catalyst and employs a bidentate directing group to dictate the regioselectivity for both unactivated terminal and internal alkenes. High functional group tolerance is observed across a wide range of electronically diverse 2-pyridones and other aza-heterocycles, including 1-hydroxyisoquinoline, 2-hydroxyquinoline, pyridazinone, pyrimidinone, and pyrazinone to obtain the corresponding products, e.g., I (X-ray single crystal structure shown). In the experiment, the researchers used many compounds, for example, 1-Hydroxyisoquinoline (cas: 491-30-5Recommanded Product: 491-30-5).
1-Hydroxyisoquinoline (cas: 491-30-5) belongs to isoquinoline derivatives. Quinoline and its derivatives are widely used as fungicides, biological agents, antibiotics, alkaloids, dyes, rubber chemicals and flavoring agents. It protonates to form salts upon treatment with strong acids, such as HCl. It forms adducts with Lewis acids, such as BF3.Recommanded Product: 491-30-5
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem