Ruthenium-Catalyzed Directed C(3)-H Olefination of N-Acetyl-1,2-dihydroisoquinolines: A Method to Achieve C3-Olefinated Isoquinolines was written by Das, Riki;Khot, Nandkishor Prakash;Deshpande, Akanksha Santosh;Kapur, Manmohan. And the article was included in Synthesis in 2019.Synthetic Route of C9H6N2O2 This article mentions the following:
A unique approach to achieve regioselective C(3)-H olefination of isoquinolines under ruthenium-catalyzed conditions has been developed. The acetyl group of N-acetyl-1,2-dihydroisoquinoline acts as a directing group for this C-H olefination strategy. Removal of the acetyl directing group by a simple method leads to a quick access to C-3 olefinated isoquinolines, e.g., I. The methodol. is a very good alternative to the traditional Heck reaction and substrates with halogen substituents are very good candidates for the transformation. In the experiment, the researchers used many compounds, for example, 5-Nitroisoquinoline (cas: 607-32-9Synthetic Route of C9H6N2O2).
5-Nitroisoquinoline (cas: 607-32-9) belongs to isoquinoline derivatives. Quinoline and its derivatives are widely used as fungicides, biological agents, antibiotics, alkaloids, dyes, rubber chemicals and flavoring agents. Other industrial applications include their use as corrosion inhibitors, preservatives, and as solvents for resins and terpenes.Synthetic Route of C9H6N2O2
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem