Determination of residual solvents in fasudil hydrochloride by headspace gas chromatography was written by Ding, Quan. And the article was included in Fujian Fenxi Ceshi in 2011.Quality Control of 5-((1,4-Diazepan-1-yl)sulfonyl)isoquinoline hydrochloride This article mentions the following:
A method for determination of ethanol, Et acetate in fasudil hydrochloride by headspace gas chromatog. on DB-624 column with FID detector was developed. Three residual solvents were completely separated The degree of separation was 19.0 for methanol and aether, 20.8 for aether and dichloromethane. Good linearity was achieved (r = 0.9993 for methanol, r = 0.9997 for aether, and r = 0.9963 for dichloromethane). The average recovery was 95.81% for ethanol, 93.11% for aether, and 92.85 for dichloromethane. The RSD of repetition was 1.8 for methanol, 3.4% for aether and 5.4% for dichloromethane. The detection limits was 0.08 μg/mL for methanol, 0.0007 μg/mL for aether, and 0.07 μg/mL for dichloromethane. In the experiment, the researchers used many compounds, for example, 5-((1,4-Diazepan-1-yl)sulfonyl)isoquinoline hydrochloride (cas: 105628-07-7Quality Control of 5-((1,4-Diazepan-1-yl)sulfonyl)isoquinoline hydrochloride).
5-((1,4-Diazepan-1-yl)sulfonyl)isoquinoline hydrochloride (cas: 105628-07-7) belongs to isoquinoline derivatives. The isoquinoline structure occurs in a considerable number of alkaloids in widely separated plant families. The Pomeranz–Fritsch reaction provides a method for the preparation of isoquinoline. This reaction uses a benzaldehyde and aminoacetoaldehyde diethyl acetal, which in an acid medium react to form isoquinoline.Quality Control of 5-((1,4-Diazepan-1-yl)sulfonyl)isoquinoline hydrochloride
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem