Isoquinoline-1-carboxylic acid (cas: 486-73-7) belongs to isoquinoline derivatives. Although isoquinoline derivatives can be synthesized by several methods, relatively few direct methods deliver the unsubstituted isoquinoline. Isoquinoline-type alkaloids show biological activities similar to those of morphinane-, protoberberine-, and benzophenanthridine-type alkaloids.Recommanded Product: Isoquinoline-1-carboxylic acid
Asymmetric synthesis and cytotoxicity of (-)-saframycin A analogues was written by Dong, Wenfang;Liu, Wei;Yan, Zheng;Liao, Xiangwei;Guan, Baohe;Wang, Nan;Liu, Zhanzhu. And the article was included in European Journal of Medicinal Chemistry in 2012.Recommanded Product: Isoquinoline-1-carboxylic acid This article mentions the following:
(-)-Saframycin A and its nineteen analogs I [R = (E)-3-F3CC6H4CH:CH, PhCONHCH2, 2-thienyl, etc.] were prepared from L-tyrosine in 24 steps, and their structures were confirmed through NMR and HRMS. The cytotoxicities of these compounds were tested against HCT-8, BEL-7402, Ketr3, A2780, MCF-7, A549, BGC-803, Hela, HELF and KB cell lines. The IC50 values of the cytotoxicity of most compounds were at the level of nM. Compound I (R = 2-furyl) showed the most potent cytotoxicity of all these compounds with an average IC50 value of 6.06 nM. In the experiment, the researchers used many compounds, for example, Isoquinoline-1-carboxylic acid (cas: 486-73-7Recommanded Product: Isoquinoline-1-carboxylic acid).
Isoquinoline-1-carboxylic acid (cas: 486-73-7) belongs to isoquinoline derivatives. Although isoquinoline derivatives can be synthesized by several methods, relatively few direct methods deliver the unsubstituted isoquinoline. Isoquinoline-type alkaloids show biological activities similar to those of morphinane-, protoberberine-, and benzophenanthridine-type alkaloids.Recommanded Product: Isoquinoline-1-carboxylic acid
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem