Shao, Hong-xia et al. published their research in Zhejiang Huagong in 2021 | CAS: 105628-07-7

5-((1,4-Diazepan-1-yl)sulfonyl)isoquinoline hydrochloride (cas: 105628-07-7) belongs to isoquinoline derivatives. Quinoline and its derivatives are widely used as fungicides, biological agents, antibiotics, alkaloids, dyes, rubber chemicals and flavoring agents. The Pomeranz–Fritsch reaction provides a method for the preparation of isoquinoline. This reaction uses a benzaldehyde and aminoacetoaldehyde diethyl acetal, which in an acid medium react to form isoquinoline.Application In Synthesis of 5-((1,4-Diazepan-1-yl)sulfonyl)isoquinoline hydrochloride

Determination of homopiperazine in fasudil hydrochloride injection by UPLC-MS/MS was written by Shao, Hong-xia;Wang, Hui;Qin, Qiu-ming. And the article was included in Zhejiang Huagong in 2021.Application In Synthesis of 5-((1,4-Diazepan-1-yl)sulfonyl)isoquinoline hydrochloride This article mentions the following:

Objective: To establish an ultra high performance liquid phase-tandem mass spectrometry (UPLC-MS/MS) method for the determination of homopiperazine in fasudil hydrochloride injection. Methods: The sample was diluted with an appropriate amount of 1 mol·L-1 sodium hydroxide solution, then extracted and injected with acetonitrile. The optimal conditions were mobile phase: methanol-0.1% formic acid aqueous solution, column: Acquity UPLC BEH C18 (2.1 mm × 100 mm, 1.7 μm). Multiple reaction monitoring (MRM) mode was performed with Electron Spray Ionization (ESI) operating in the pos. ionization mode. Results: Homopiperazine had a good linear relationship within 360-2400 μg·L-1 (correlation coefficient r = 0.9977). The relative average deviation (RSD) of the repeatability tests was 1%, the recovery rate was 87-100%, and the LOD (S/N was about 3) was 60 μg·L-1. The sample solution was stable within 24 h at room temperature Conclusion: This experiment has established a method for the determination of homopiperazine in fasudil hydrochloride injection. This method has the advantages of simple pretreatment, rapid anal., high sensitivity, accurate determination results, and strong specificity, and can be applied to the quality monitoring of drugs. In the experiment, the researchers used many compounds, for example, 5-((1,4-Diazepan-1-yl)sulfonyl)isoquinoline hydrochloride (cas: 105628-07-7Application In Synthesis of 5-((1,4-Diazepan-1-yl)sulfonyl)isoquinoline hydrochloride).

5-((1,4-Diazepan-1-yl)sulfonyl)isoquinoline hydrochloride (cas: 105628-07-7) belongs to isoquinoline derivatives. Quinoline and its derivatives are widely used as fungicides, biological agents, antibiotics, alkaloids, dyes, rubber chemicals and flavoring agents. The Pomeranz–Fritsch reaction provides a method for the preparation of isoquinoline. This reaction uses a benzaldehyde and aminoacetoaldehyde diethyl acetal, which in an acid medium react to form isoquinoline.Application In Synthesis of 5-((1,4-Diazepan-1-yl)sulfonyl)isoquinoline hydrochloride

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem