Sequential One-Pot Vilsmeier-Haack and Organocatalyzed Mannich Cyclizations to Functionalized Benzoindolizidines and Benzoquinolizidines was written by Outin, Johanne;Quellier, Pauline;Belanger, Guillaume. And the article was included in Journal of Organic Chemistry in 2020.Recommanded Product: 6,7-Dimethoxy-3,4-dihydroisoquinoline This article mentions the following:
The development of new one-pot sequential cyclizations involving a Vilsmeier-Haack reaction followed by an organocatalyzed Mannich reaction is reported. This synthetic strategy gives access to functionalized indolizidines and quinolizidines in one operation from readily synthesized precursors. Yields and diastereoselectivities are good to excellent when formamides are used to trigger the key step, bearing either an electron-rich aryl or a pyrrole as the nucleophilic partner in the first cyclization. In the experiment, the researchers used many compounds, for example, 6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1Recommanded Product: 6,7-Dimethoxy-3,4-dihydroisoquinoline).
6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1) belongs to isoquinoline derivatives. Being an analog of pyridine, isoquinoline is a weak base, with a pKa of 5.14. Other industrial applications include their use as corrosion inhibitors, preservatives, and as solvents for resins and terpenes.Recommanded Product: 6,7-Dimethoxy-3,4-dihydroisoquinoline
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem