With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7651-81-2,Isoquinolin-3(2H)-one,as a common compound, the synthetic route is as follows.
Example 9; 3-Trifluoromethylsulfonate-isoquinoline; Triflic anhydride (2.03 g) was added dropwise to a stirred solution of 3-hydroxy-isoquinoline (950 mg) in pyridine (7.0 mL) at 0 C. After 10 minutes the icebath was removed and the reaction was stirred at room temperature for 16 hours. The solution was then diluted with water and extracted with CHCl3, the organic extracts were washed with brine and dried over Na2SO4. Evaporation of the solvents and purification over SiO2 (EtOAc:Hex, 1:1) yielded 1.70 g (94%) of product. Mp 33.3-33.9 C. 1H NMR (CDCl3): delta (ppm) 9.04 (s, 1H), 8.03 (d, J=8.3 Hz, 1H), 7.90-7.62 (m, 3H) 7.55 (s, 1H).
The synthetic route of 7651-81-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Smits, Rogier Adriaan; Lim, Herman Dirnawan; Leurs, Regorius; De Esch, Iwan Jozef Philomena; US2010/16293; (2010); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem